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  • DoorDash agrees to acquire Instacart for about $17 billionTech
  • Intel shares plunge after hours as Israel fab blast and PC slowdown weigh on outlookTech
  • Amazon earnings call: AWS backlog reaches $578 billion, 2027 spending to rise "meaningfully"Tech
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  • Intel Q3 2026 earnings: $16.5 billion revenue, data center up 78%Tech
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Home/Tech/NVIDIA and UW Institute for Protein Design Release RFD4-Proteina Open Model
VERIFIEDBy Xavier Rivera·Wednesday, October 21, 2026 at 6:44 AM AST·1.5 min read

NVIDIA and UW Institute for Protein Design Release RFD4-Proteina Open Model

NVIDIA and the UW Medicine Institute for Protein Design released RFD4-Proteina, an open protein design model available today through partners including Hugging Face, Google Cloud, OpenAI and Anthropic's Claude Science. NVIDIA also announced an adaptive radiotherapy collaboration with Siemens Healthineers and new scientific-agent work on its BioNeMo platform.

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NVIDIA and UW Institute for Protein Design Release RFD4-Proteina Open Model
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NVIDIA on Wednesday announced a set of healthcare and life sciences collaborations at GTC Berlin, led by RFD4-Proteina, a new open protein design model built with the UW Medicine Institute for Protein Design.

RFD4-Proteina
RFD4-Proteina is an NVIDIA BioNeMo open model that combines programmable protein design with search, letting scientists and agents generate, search and refine designs using molecular inputs, constraints and scoring objectives. NVIDIA says that in testing reported in the research draft, the model achieved higher computational design success rates and generation throughput than the evaluated baselines across four benchmark suites: protein binding, small-molecule binding, enzyme scaffolding and DNA binding. It is available today through partners including Amazon Bio Discovery, Anthropic's Claude Science, Benchling, Databricks, Google Cloud, Hugging Face, Nebius, OpenAI and Tamarind Bio.
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Siemens Healthineers and adaptive radiotherapy
Siemens Healthineers and NVIDIA are collaborating on the next generation of adaptive radiotherapy. Nemotron open models are being explored for agentic treatment co-planning, which could be combined with CUDA-accelerated dose calculation for patient-specific simulation and the Holoscan platform for live sensor data. "Treatment should adapt to the patient, not the other way around," said Arthur Kaindl, head of Varian, the Siemens Healthineers cancer-care business.
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Scientific agents
Benchling, Biolevate, Boltz, Automata, Hologen and Therna Biosciences are using BioNeMo, Nemotron and other NVIDIA technologies to build scientific agents and tools for drug design and lab workflows. Genedata's AI co-scientist will coordinate protein design and testing in the protein design foundry within Danaher's autonomous lab, using RFD4-Proteina.

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Avelios, Corti, Dedalus, Dawn Health and Sword are building on Nemotron for AI scribes, clinical support and patient services. PolyAI is using NVIDIA Agent Toolkit for a multilingual dialog deployment with Corilus, whose network spans more than 70,000 healthcare professionals in Belgium and France. Apian and VitVio are using Cosmos and Omniverse to build hospital digital twins.
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